Objective: To investigate the influence of ligustrazine hydrochloride injection combined with Buyang Huanwu Tang to blood viscosity and blood coagulation factor on acute cerebral infarction. Method: One hundred and ten patients with acute cerebral infarction were randomly divided into control group(55 cases) and observation group(55 cases) by random number table. Both groups received aspirin enteric-coated tablets

100 mg/time

1 time/day

dipyridamole tablets

50 mg/time

3 time/day. Based on the treatment of control group

patients in observation group added ligustrazine hydrochloride injection combined with Buyang Huanwu Tang. Courses of treatment in two groups were both 14 days. Scores of neurologic impairment were graded by national institutes of health stroke scale(NIHSS). Before and after treatment

levels of blood rheology target

D-dimer(D-D)

maximum platelet aggregation rate(MPAR)

von Willebrand factor(vWF)

prothrombin time(PT)

activated partial thromboplastin time(APTT)

thrombin time(TT)

fibrinogen(FIB) were detected. Result: Total effective rate in observation group was 90.91% higher than that in control group(76.36%)

with significant difference(P<0.05). At the fourteenth day after treatment

NHISS score in the observation group was lower than that in control group(P<0.05). Levels of D-D

MPAR and vWF were lower than those in control group(P<0.05

P<0.01). Levels of whole blood viscosity(high and low shearing)

plasmic viscosity and erythrocyte sedimentation rate were also lower than those in control group(P<0.05

P<0.01). Compared with the data before treatment

levels of PT

APTT and TT in both groups increased(P<0.01)

and they were more obvious in observation group(P<0.05). And FIB decreased in both groups compared with the data before therapy

it was more obvious in observation group(P<0.01). Conclusion: Based on the conventional western medicine treatment

ligustrazine hydrochloride injection combined with Buyang Huanwu Tang on can improve blood fluidity with acute cerebral infarction patients

enhance the neural function recovery of patients and increase the clinical curative effect.