Objective: To systematically evaluate the safety and efficacy of Xiaoqinglong Tang in treating cough variant asthma in children. Method: We searched Cochrane Library

Pubmed

Embase

CNKI

CBM

VIP and Wanfang Data through computer for data as at June 2015.All of randomized controlled trials(RCTs) of Xiaoqinglong Tang in treating on cough variant asthma in Children were searched

and research literatures included in the RCTs were also traced. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies and made a Meta-analysis by using RevMan 5.3 software. Result: Totally 10 RCTs involving 961 patients were included into the study. The Meta-analysis results showed that compared with the pure application of western medicine

Xiaoqinglong Tang can significantly improve the clinical effective rate[OR=2.49

95%CI(1.12

5.54)

P=0.0002]

with statistical significant differences. In terms of adverse reactions

only one study showed adverse reactions

including irritability

sleepiness and nausea reaction in children. The treatment group showed no such problem in the process of treatment(0). While the control group had 5 cases with similar adverse reactions(13.89%

P<0.05)

with statistically significant differences in both groups. Conclusion: Xiaoqinglong Tang in treating cough variant asthma in children can effectively improve the clinical effective rate. However

due to the low methodology and quality and small sample size of included RCTs in this study

more randomized

double-blind trials with a large sample size are required to further verify the efficacy and safety of Xiaoqinglong Tang in treating cough variant asthma in children.