Objective: To systematically evaluate the safety and efficacy of Xiaochaihu Tang in treating apoplectic vertigo. Method: We searched the CochraneLibrary

Pubmed

Embase

CNKI

CBM

VIP and Wanfang Data through computer for data as at June19

2015.All of randomized controlled trials(RCTs) of Xiaochaihu Tang in treating apoplectic vertigo were searched

and research literatures included in the RCTs were also traced. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies and made a Meta-analysis by using RevMan 5.3 software Result:Totally 12 RCTs involving 1181 patients were included into the study. The Meta-analysis results showed that compared with the pure application of western medicine

Xiaochaihu Tang can significantly improve the clinical effective rate[OR=7.53

95%CI(5.08

11.17)

Z=10.05

P<0.00001]

reduce plasma viscosity[MD=-0.49

95%CI(-0.53

-0.45)

Z=21.99

P<0.00001]

with statistical significant differences. In the adverse reactions

only two study showed the adverse reactions in follow-up reports:the experiment group showed no serious adverse eventsduring treatment

whereas the control group showed 5 cases of dry mouth

5 cases of sleepiness and7 cases of intestines and stomach discomfort during treatment

with statistically significant differences(P<0.5). Conclusion: Xiaochaihu Tang in treating apoplectic vertigo can effectively improve the clinical effective rate and reduce plasma viscosity and is advantageous over the simple administration with western medicine. However

due to the low methodology and quality and small sample size of included RCTs in this study

more strict multicenter

randomized

double-blind trials with a large sample size are required to further verify the efficacy and safety of Xiaochaihu Tang in treating apoplectic vertigo.