Objective: To investigate compatibility between Panacis Quinquefolii Radix extract and different pharmaceutical excipient

in order to provide a reference for basic formulation design of solid preparations of Panacis Quinquefolii Radix extract. Method: HPLC was employed to determine contents of ginsenoside Rg1

Re

Rb1

Rc

Rb2

Rb3

Rd with mobile phase of acetonitrile-water for gradient elution and detection wavelength at 203 nm.Taking appearance and total content of index components as indexes

single factor tests were used to investigate compatibility of extract and different pharmaceutical excipient. Result: Contents of ginsenosides decreased significantly under high humidity condition and appearance changed

in other conditions

these indexes relatively stable. Conclusion: Lactose

microcrystalline cellulose

sodium carboxymethyl starch sodium and magnesium stearate can be used as suitable material for solid preparation of Panacis Quinquefolii Radix extract.High humidity condition will affect stability of preparation of Panacis Quinquefolii Radix extract

so it should be kept closed in order to prevent moisture absorption.