Objective: To investigate anti-inflammatory effect of Jinqiao Reduqing granules and spray drying powder with different drying process. Method: Eighty-four mice were randomly divided into model group

aspirin group(0.2 g·kg-1)

Reduping group(21.84 g·kg-1)

Jinqiao Reduqing granules group(11.7 g·kg-1) and Jinqiao Reduqing spray drying powder group(5.85

11.7

23.4 g·kg-1)

twelve for each group;then with xylene-induced inflammation

mouse ear swelling was measured.In addition

an alternative 84 mice were divided into groups and treated with the same method;inflammation was induced by traperitoneal injection of acetic acid

and absorbance of peritoneal fluid was measured at 590 nm.Anti-inflammtory effect was evaluated by reducing xylene-induced ear swelling level and glacial acetic acid-induced abdominal capillary permeability. Result: Mouse ear swelling of each group were(18.5±3.2)

(9.3±2.0)

(14.6±4.2)

(14.8±2.3)

(14.8±3.6)

(13.9±3.2)

(13.4±2.2) mg

respectively.Compared with the model group

swelling and swelling rate of each drug administration groups had significantly decreased.Absorbance values of each group were 0.677±0.121

0.321±0.094

0.558±0.107

0.537±0.065

0.583±0.195

0.523±0.137 and 0.512±0.099

respectively. Conclusion: Jinqiao Reduqing spray drying powder and granules has a certain anti-inflammatory effect

they can obviously decrease mouse ear swelling and capillary permeability in abdominalcavity.But at the same dose

anti-inflammatory effect of Jinqiao Reduqing spray drying powder was more powerful than that of Jinqiao Reduqing granules

and under the same doses of equal clinical multiple

anti-inflammatory effect of Reduping granules was slightly weaker than that of Jinqiao Reduqing spray drying powder.