Objective: To investigate the effect of Danlong Xingnao decoction on the angiogenesis and the angiopoitin 1(Ang-1) protein expression of rats with cerebral ischemia-reperfusion. Method: A rat model of the middle cerebral artery occlusion/reperfusion(MCAO) was created by using the suture method

and the blood reperfusion was performed 2 hours later. The rats were randomly divided into six groups

high-dose

medium-dose and low-dose(14.76

7.38

3.69 g·kg-1) Danlong Xingnao decoction groups

nimodipine(10.8 mg·kg-1) group

model group and sham group. The rats were given by gavage once a day for 7 days. The microvessel vascular density(MVD) were observed and the expression of Ang-1 at protein level were studied by the immuneohistochemical method. Result: Compared with the sham group

the microvessel density

Ang-1 in model group were higher significantly(P<0.05). Compared with the model group

Danlong Xingnao decoction groups showed significantly higher levels of MVD and the protein expression of Ang-1(P<0.05

P<0.01). Conclusion: Danlong Xingnao decoction could promote angiogenesis and protect ischemic brain tissue in rats. Its mechanism may be correlated with the up-regulation of the expression of Ang-1.