Objective: To observe the effect of Heidihuang Wan on spleen and stomach pattern

nutritive status and gastrointestinal hormone in chronic renal failure(CRF). Method: The CRF patients were randomly divided into two groups

59 cases in observation group and 59 cases in control group. On the basis of general treatment

the patients in observation group were also treated with Heidihuang Wan

9 g/time

3 times/day. The patients in control group were treated with Niaoduqing granules 9 g/time

3 times/day. The treatment course was 8 weeks in both groups. The scores of spleen and stomach pattern before and after treatment were graded;changes in the index of hemoglobin(Hb)

albumin(ALb)

prealbumi(PA)

total cholesterol(TC)

the level of gastrin(GAS)

motilin(MTL)

somatostatin(SS)

Leptin and neuropeptide Y(NPY) before and after treatment were detected. Result: The total effective rate of spleen and stomach pattern in the observation group was 81.35%

superior to 67.80% in the control group(P<0.05). After treatment

the level of Hb was significantly higher(P<0.05)

and the result in the observation group was better than that in the control group(P<0.05). After treatment

ALb and PA levels in both groups were increased obviously(P<0.05) and the increase in the observation group was more significant(P<0.05). After treatment

levels of GAS and MTL were decreased in both groups(P<0.05). After treatment

SS level was significantly increased in the observation group(P<0.05)

which was more significant than that in the control group(P<0.05). After treatment

levels of Leptin and NPY were decreased in the observation group(P<0.05)

which was more significant than that in the control group(P<0.05). Conclusion: Heidihuang Wan can well relieve TCM pattern of the spleen and stomach

and benefit the nutrient state of the patients with CRF. Its mechanism may be related to improving the gastrointestinal function disturbance.The methods of reinforcing spleen(stomach) has clear short-term effect in the treatment of CRF.