Objective: To observe the therapeutic efficacy of Tongfu Xingshen decoction on the recovery of nerve function after minimally invasive surgery for hypertensive cerebral hemorrhage(phlegm-heat fu organ sthenia and wind phlegm blocking) and observe its influence on the serum level of interieukin-6(IL-6)

tumor necrosis factor-α(TNF-α)

and matrix-metalloproteinase-9(MMP-9). Method: Ninety-six patients with hypertensive cerebral hemorrhage surgery were randomly divided into control group and treatment group(48 cases in each group) by admission sequence. Based on routine therapy

patients of control group received edaravone therapy

ivgtt. Based on the treatment of control group

patients in treatment group were also treated with additional Tongfu Xingshen decoction. Course of treatment was 6 weeks for both groups. The Glasgow coma scales(GCS)

neurological deficit score

and Barthel index were compared between two groups. Serum IL-6

TNF-α

and MMP-9 levels before and after treatment were detected. Result: The clinical efficacy of treatment group was superior to that in control group by ridit analysis(P<0.05). After treatment of 1 and 2 weeks

GCS scores of both groups were continuously increased(P<0.01)

and GCS scores in treatment group were significantly higher than those in control group(P<0.01). After treatment

Barthel Index scores in treatment group were higher than those in control group

and National Institute of Health Stroke Scale(NIHSS) scores were lower than those in control group(P<0.01). After treatment

serum levels of IL-6

TNF-α and MMP-9 in treatment group were lower than those in control group(P<0.01). Conclusion: Tongfu Xingshen decoction combined with intravenous drip of edaravone has good effect on the recovery of nerve function after minimally invasive surgery for hypertensive cerebral hemorrhage(phlegm-heat fu organ sthenia and wind phlegm blocking)

and its mechanism may be related with inhibiting the inflammatory response and MMP-9.