Objective:To optimize preparation process of Jieyu Shuxin granules and set up its quality standard. Method:According to characteristics of granules

wet granulation was employed

kinds and amounts of excipients in granules were optimized with indexes of solubility

clarity and powder ratio.With qualified rate of particle size as index

orthogonal test was adopted to optimize formulation process by taking ethanol concentration

amounts of dextrin and xylitol as factors.HPLC-ELSD was employed to determine contents of jujuboside A and B in this granules with acetonitrile-water (35:65)as mobile phase and column temperature at 35℃. Result:Xylitol had the best clarity with minimum powder ratio.Optimum recipe ratio was dry extract-xylitol-dextrin (0.5:15:7)

50% ethanol as a adhesive.Contents of jujuboside A and B in Jieyu Shuxin granules were 0.683

1.369 mg·g-1

respectively. Conclusion:These methods are proved to be reliable

sensitive and specific

which can be used in quality control of Jieyu Shuxin granules.