Objective:To cover up bad taste of paeonol and prepare paeonol common melting substance granules

and then investigate in vitro dissolution of this granules. Method:Taking glyceryl behenate as masking material

common melting substance granules were prepared by melting quenching method.With proportion of paeonol and glyceryl behenate

the amount of PEG6000 and particle size as factors

orthogonal test was adopted to optimize formulation technology by taking taste masking effect and dissolution in 60 min as comprehensive evaluation index.Dissolution of paeonol was determined by UV spectrophotometry. Result:The best formulation process of paeonol common melting substance granules was as following:paeonol-glyceryl behenate (1:3.5)

the amount of PEG6000 accounted for 13% of total content of paeonol and glyceryl behenate

particle size of 80-100 mesh.Particles size had a significant impact for taste masking effect and dissolution of paeonol common melting substance granules

dissolution of paeonol in 60 min was more than 70%. Conclusion:Paeonol common melting substance granules has good taste masking effect.This optimized process is simple and feasible.