Objective:To optimize clarification technology of Yinma oral liquid. Method:A logarithmic equation for turbidity determination was established.Orthogonal test was adopted to investigate effects of chitosan dosage

pH value

clarification temperature and time on overall desirability of the content of chlorogenic acid

solid content and turbidity.Particle size and Zeta potential was used for stability analysis. Result:Optimal clarification technology conditions was as follows:chitosan dosage of 0.1%

stirring time of 10 min

pH 4.5

heated for 2 h at 40℃ and refrigerated 12 h at 4℃.The content of chlorogenic acid was 0.0855 g·L-1

solid content was 6.60 g·L-1 and turbidity was 9.967 NTU.Average particle size of 80.9% particles was 1.170μm and average Zeta potential of 98.2% particles was -0.778 mV. Conclusion:This clarification process is stable and feasible with a good clarifying effect

and Yinma oral liquid system is stable after clarification.