Objective:To optimize extraction process of Xiaoer Feike oral liquid and provide a reference for industrial production of this preparation. Method:Developing the antitussive

antiasthmatic and expectorant experiments

the best extraction method was optimized.Single factor tests was adopted to investigate effects of the amount of water

soaking time and extraction time on extraction process of volatile oil.With contents of ginsenoside Rb1 and hesperidin

dry extract yield as comprehensive evaluation index

orthogonal design was adopted to predict ethanol process conditions by taking ethanol volume

extraction time and times as factors. Result:Optimum extraction process of volatile oil were as follows:adding 8 folds of water

extracting for 8 h after being soaked 0.5 h;yield of volatile oil was 0.81 mL.The best conditions for ethanol extraction process were extracting thrice with 8 times of 75% ethanol

2 hours for per time.Extracting amounts of ginsenoside Rb1 and hesperidin were 1.59

2.84 mg·g-1

dry extract rate was 19.53%. Conclusion:These optimized technologies are stable and reliable for industrial production of Xiaoer Feike oral liquid.