Objective:To investigate the clinical effect of Tangmaikang particles in combination with intensive insulin therapy in the treatment of type 2 diabetes mellitus (T2DM) and its effects on blood lipids and endothelin-1(ET-1). Method:The 124 cases of T2DM meeting the inclusion criteria in people's hospital of Binzhou were randomly divided into control group and observation group equally. Besides conventional treatments

the control group was also treated with intensive insulin therapy

while the observation group was also treated with Tangmaikang particles combined with intensive insulin therapy. Then

the curative efficacy

glucose-related indicators

level of blood lipids

ET-1 and incidence of hypoglycemia were compared between two groups. Result:After treatment

the effective rate in the observation group was 83.9%

significantly higher than 67.7% in the control group (P<0.05). In comparison with the control group after the treatment

glucose-related indicators in observation group were as follows:fasting plasma glucose (FPG) (7.2±0.4)VS(7.9±0.5)mmol·L-1

2 h plasma glucose (2 hPG)(8.5±0.5)VS(9.4±0.6) mmol·L-1

glycosylated hemoglobin A1c(HbA1c)(7.0%±0.4%)VS(7.6%±0.5%). The levels were respectively significantly lower in the observation group (all P<0.05). As to blood lipids

level of total cholesterol(TC) (4.36±0.82)VS(5.21±0.94)mmol·L-1

triglyceride(TG)(1.93±0.68)VS(2.20±0.53)mmol·L-1

low density lipoprotein cholesterol(LDL-C)(3.10±0.54)VS(3.90±0.64)mmol·L-1

respectively statistically lower in the observation group. And level of high density lipoprotein cholesterol(HDL-C)(1.59±0.35)VS (1.29±0.32)mmol·L-1was statistically higher in the observation group than that in the control group after the treatment (all P<0.05). And level of ET-1(70.2±7.4)VS(75.6±8.3) ng·L-1 in the observation group was found statistically lower than that in the control group after the treatment (P<0.05). During the treatment

the incidence of hypoglycemia was 8.1% in the observation group and 4.8% in the control group

with no significant difference. Conclusion:Tangmaikang particles combined with intensive insulin therapy is effective for T2DM

which can significantly increase curative efficacy

improve blood glucose and blood lipids indicators and lower the level of ET-1

in addition

it would not increase the incidence of hypoglycemia

thus it is worthy for promotion in clinical use.