Objective:To evaluate the efficacy and safety of compound Kushen injection for cancer-related pain

and provide information for clinical application and traditional Chinese medicine(TCM) injection research. Method:Computer retrieval of randomized controlled trials (RCTs) on compound Kushen injection for cancer-related pain was done. No language or blinding restriction was used. Quality of the literature and methodological quality of RCTs was assessed According to the methods recommended by Cochrane center. RevMan 5.3 was used for Meta-analysis on the efficacy and safety of compound Kushen injection. Result:The 21 randomized controlled trials were included in the study

involving 1903 patients

and 12 literature were used for Meta-analysis according to different treatment groups combined with analgesic. Compared with the western analgesic alone

compound Kushen injection combined with western analgesic had the following relative risk (RR) and 95% CI were[n=1115

RR=1.15

95%CI(1.09

1.21)]

P<0.00001]. In respect of adverse effects

the combined effects showed that the RR and CI were as follows:constipation[n=481

RR=0.50

95%CI(0.33

0.78)

P=0.002]

nausea[n=421

RR=0.49

95%CI(0.24

0.99)

P=0.05]

vomit[n=208

RR=0.33

95%CI(0.09

1.17)

P=0.09]

dysuria[n=268

RR=0.38

95%CI(0.09

1.60)

P=0.19]. There were no serious adverse events. Conclusion:Compound Kushen injection combined with western analgesic had better efficacy than analgesic alone

and could assisted to reduce the adverse events of analgesic. Although in recent years

the quantity and quality of RCTs have a tendency to increase year by year

the research level remains to be enhanced through scientific design and normative report.