Objective:To evaluate the effectiveness and safety of Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section. Method:Search was conducted in the following databases:PubMed

EMbase

Cochrane Library

CNKI

VIP and WanFang Data during the period from the established time to September 2014.Randomized controlled trial (RCT) of Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section were included

and its adverse drug reaction

postpartum bleeding and postpartum hemorrhage rate were observed. The quality of included studies was assessed according to Cochrane Methods 5.1 for systematic review

and Meta-analysis was conducted using RevMan 5.1 software. Result:A total of 25 studies involving 5709 patients were included. The Meta-analysis results indicated significant difference in intra-operative bleeding volume between Yimucao injection combined with oxytocin group and control group[MD=-44.96

95%CI(-64.15

-25.76)

P<0.00001];showed significant difference in 2 hours postoperative bleeding between the two groups[MD=-38.25

95%CI(-51.59

-24.90)

P<0.00001];showed significant difference in 24 hours postoperative bleeding between the two groups[MD=-49.26

95%CI(-65.66

-32.85)

P<0.00001]. The Meta-analysis showed a significant reduction in the risk of postpartum hemorrhage rates between two groups[OR=0.33

95%CI (0.25

0.43)

P<0.00001]. Side effect rates showed no significant difference between two groups[OR=0.78

95%CI(0.41

1.47)

P=0.44]. Conclusion:Compared with control group

Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section can significantly reduce postpartum bleeding and postpartum hemorrhage rate

without increasing the side effects for patients. We conclude that Yimucao injection combined with oxytocin is more appropriate for preventing postpartum hemorrhage during cesarean section. However

due to the limitation of both quantity and quality of included studies

this conclusion should be further confirmed with more high quality and large multicenter randomized controlled clinical trials.