Objective: To optimize extraction process and pharmaceutical formulation of Wuwei Jinse dispersible tablets. Method: Taking composite score of contents of total polyphenols and gallic acid

dry extract rate as index

orthogonal test was adopted to investigate influence of extraction time

extraction times

the amount of water on water extraction process.With appearance

hardness and dispersion uniformity time as indexes

molding process of dispersible tablets was optimized by single factor tests. Result: Optimum extraction process consisted of adding 10-fold of waters

extracting 3 times

90 min for each time.Yield of total polyphenols was 6.29%

the content of gallic acid was 398.37 mg

dry extract rate was 24.28%.This dispersible tablets were made up of amylum pregelatinisatum

microcrystalline cellulose

croscarmellose sodium and micropowder silica gel

and it can be disintegrated completely and dispersed uniformly within 130 s. Conclusion: Optimized extracting process and pharmaceutical formulation are feasible and stable for industrial production of Wuwei Jinse dispersible tablets.