Objective: To investigate the effect of Se-enriched Ganoderma lucidum polysaccharides on blood lipids

inflammatory factors

stearoyl coenzyme1 (SCD1) and peroxisome proliferator-activated receptor α (PPARα) expression in rats with nonalcoholic fatty liver disease (NAFLD). Method: One hundred and twenty SD rats were randomly divided into normal group

high-fat diet group (model group)

polyene phosphatidylcholine(50 mg·kg-1) group

Se-enriched G. lucidum polysaccharides low

medium and high dose groups (0.3

0.6

1.2 g·kg-1

ig). Rats were given high-fat and high-sucrose diet for 12 weeks to establish NAFLD models. After treatment for 4 weeks and 8 weeks

the rats were sacrificed half and half to detect high-density lipoprotein-C (HDL-C)

low-density lipoprotein-C (LDL-C)

interleukin-1α (IL-1α)

interleukin-1β (IL-1β)

tumor necrosis factor-α (TNF-α) in serum

as well as SCD1 and PPARα levels in liver homogenates. Result: Compared with the normal group

fat vacuoles were obvious and associated with inflammation after 4 weeks treatment in model group. Compared with the model group

Se-enriched G. lucidum polysaccharides treatment groups significantly decreased fat particles. Compared with the normal group

HDL-C

LDL-C

IL-1α

IL-1β and TNF-α levels were significantly increased in the model group after 8 weeks of treatment

Compared with the model group

HDL-C

LDL-C

IL-1α

IL-1β and TNF-α levels were significantly decreased in three Se-enriched G. lucidum polysaccharides treatment groups (P<0.05)

and they were further decreased after 8 weeks of treatment

but with no significant difference from the polyene phosphatidylcholine group. Compared with the normal group

SCD1 and PPARα mRNA and protein expressions in liver tissues were significantly decreased in model group after 4 weeks treatment. Compared with the model group

SCD1 and PPARα mRNA and protein expressions in liver tissues were significantly increased in three Se-enriched G. lucidum polysaccharides treatment groups

but the effect of polyene phosphatidylcholine was better than Se-enriched G. lucidum polysaccharides on the improvement of SCD1 and PPARα mRNA and protein expressions. Conclusion: Se-enriched G. lucidum polysaccharides could improve SCD1 and PPARα expressions in liver tissues of NAFLD rats

and could regulate blood lipids

and inflammation although its effect was inferior to polyene phosphatidylcholine.