Objective: To observe the effect of Danhong injection on blood rheology

inflammatory cytokines and endothelial function in patients with thrombotic shallow phlebitis. Method: Sixty-three patients with thrombotic shallow phlebitis hospitalized from February 2014 to January 2015 in our hospital were randomly divided into two groups. The patients in control group received aspirin enteric-coated metformin hydrochloride and low molecular weight heparin calcium injection treatment

on the basis of control group

the patients in research group also received Danhong injection for 2 weeks. Then the curative effect

hemodynamic changes

inflammation

and endothelial function before and after treatment of two groups were observed and compared. Result: ①Curative effect:total effective rate in research group was 92.86%

higher than 76.19% in control group

with statistically significant difference between group (P<0.05). ② Blood rheology:after treatment

blood plasma viscosity

whole blood high shear reductive viscosity

whole blood low shear reduction viscosity

blood sedimentation

erythrocyte aggregation index

erythrocyte deformation index

and fibrin had varying degrees of decline in two groups

with significant difference (P<0.05);and compared with the control group

the decline was more significant in research group

with significant difference (P<0.05). ③Inflammatory cytokines:after treatment

interleukin-1 (IL-1)

IL-6

tumor necrosis factor-α (TNF-α)

high sensitive C-reaction protein (hs-CRP) were reduced significantly in both groups (P<0.05)

and the levels in research group were all significantly less than those in control group (P<0.05). ④ Endothelial function:after treatment

endothelin

and von willebrand factor were reduced significantly in bith groups (P<0.05)

and the levels in research group were significantly less than those in control group (P<0.05). Conclusion: Danhong injection can effectively improve the clinical symptoms of thrombotic shallow phlebitis

improve hemodynamics and endothelial function

and inhibit inflammatory reaction.