Objective: To systemically review the effect of ginkgo biloba extract (GbE) on microalbuminuria and renal function in patients with diabetic nephropathy (DN). Method: Literature were retrieved from PubMed

CNKI

VIP

CBM and Wanfang database to select the randomized controlled trials (RCT) where conventional treatment was as the control group

and GbE was also used on the basis of conventional treatment as the experimental group to study its effect on microalbuminuria and renal function in patients with diabetic nephropathy. RevMan 5.2 software was used for Meta analysis after 2 researchers selected the literature according to inclusion and exclusion criteria

extracted the data and evaluated the methodological quality in the study. Result: 16 RCTs were included

involving 1 212 patients. Meta-analysis showed that compared with control group

experimental group can significantly decrease urine albumin excretion rate (UAER)[SMD=1.00

95%CI(0.70

1.30)

P<0.01]and

24-hour urinary protein quantity[SMD=1.00

95%CI (0.70

1.30)

P<0.01] and 24 h urine protein quantitation[SMD=1.00

95%CI (0.70

1.30)

P<0.01]

but can not significantly decrease serum creatinine (SCr)[SMD=0.11

95%CI (-0.03

0.26)

P>0.05]. Conclusion: Ginkgo biloba extract can significantly reduce the microalbuminuria in patients with diabetic nephropathy

but has no significant improvement for renal function. Due to the restrictions of the quality of included studies

this conclusion needs to be further verified by large sample and high quality RCTs.