Acute gouty arthritis (AGA) is a crystal joint disease caused by uric acid crystal deposition in the joints which was caused by purine metabolic disorder. By reviewing the literature reports in recent years on pharmacological effects and mechanism of natural products and their effective components against AGA

and focusing on the pathogenesis of urate crystal-induced acute gouty arthritis in animal models

we collected

summarized and analyzed the literature on targets and pharmacological action mechanism of natural products and their effective components against acute gouty arthritis. Studies have shown that the main effective components in natural products against acute gouty arthritisinclude flavonoids

alkaloids

polyphenols

saponins

and coumarin

etc. They fight against the acute gouty arthritis through anti-inflammatory

analgesic and inhibiting the release of inflammatory mediators as well as its related signaling pathways

antioxidant mechanism and multiple drug targets. Targets for the treatment of acute gouty arthritis are single in western medicine

with more serious side effects

thus not conducive to control the recurrence of acute gouty arthritis. Natural products in traditional Chinese medicines have a thousand years of history and experience in prevention and treatment of acute gouty arthritis. Compared with the western medicine

natural medicine has shown great potential and advantages of multiple targets and few side effects for the acute gouty arthritis. In recent years

more and more researchers use experimental pharmacology and molecular biology method to study the effect of natural products and their effective components against acute gouty arthritis

and have achieved gratifying results.