Objective: To optimize process of polydatin being transformed into resveratrol by response surface methodology for increacing the content of resveratrol and promoting resource development of Polygoni Cuspidati Rhizoma et Radix. Method: Considering yield of resveratrol as index

based on single factor experiments

response surface methodology was adopted to optimize transformation process by taking the amount of enzyme

temperature

pH and time as factors.UV was employed to determine the content of resveratrol at 305 nm. Result: Optimum technological conditions were as follows:enzyme dosage of 463 μL

temperature at 43 ℃

pH of 5.0

conversion time of 153 min;yield of resveratrol was 16.46 mg · g-1

whose deviation was small by comparing with the theoretical value of 16.52 mg · g-1

which was 3.58 times to before optimization and 1.66 times of the best enzyme hydrolysis process. Conclusion: Response surface analysis is suitable for optimizing transformation process of resveratrol

this process is feasible

which is a beneficial reference for reducing industrial production costs of resveratrol.