Objective: To optimize preparation process of compound Qiancao tablets. Method: Pharmacodynamic test was adopted to screen extraction method

orthogonal test was used to optimize conditions of extracting temperature

solvent amount and extracting time in extraction process of compound Qiancao tablets

with extracting rates of mollugin and hydroxynaphthoquinones as indexes.Molding process of compound Qiancao tablets was optimized by single factor tests. Result: Optimal extraction and molding processes were as follows:extracted twice with 10-fold and 8-fold 95% ethanol refluxing at 95 ℃

1 hour for per time

then vacuum dried to obtain extract;added MCC and CMS-Na into extract

mixed with 5% PVP-K30 as an adhesive to obtain wet granules

dried granules and granulated through a twenty-mesh sieve;added proper amount of magnesium stearate for tableting with coating weight of 1%.Dry extract rate was 4.57%

contents of mollugin and hydroxynaphthoquinones in extract were 6.68% and 10.81%.Hardness of the tablets was 4.5 kg and disintegration time was 25 min with good coating performance. Conclusion: These optimized processes are reasonably practicable

which can be applicable to industrial production of compound Qiancao tablets.