Objective: To study the effects of different decoction methods on the quality of Shenqi Yangxue preparations

and provide the evidence for choosing the preparation method of tonifying recipes. Method: Ratio of extraction

n-BuoH extract content and astragaloside Ⅳ content were used as the evaluation indexes. UPLC-Q-TOF-MS method was adopted to determine the astragaloside Ⅳ content. ACQUITYTM C18(2.1 mm×50 mm

1.7 μm)column was used with acetonitrile-0.1% formic acid water as the mobile phase for gradient elution. The flow rate was set to 0.45 mL · min and the column temperature was 40 ℃. The mass spectra were obtained by Xevo G2 Q-TOF with electrospray ionization source in negative ion mode to determine the content of astragaloside IV[M＋COOH]-

m/z 829.45. Result: astragaloside Ⅳ had good linear relationship within the range of 9.8×10-5-9.8×10-3 μg(r=0.999 0)with an average recovery rate of 100.32%.The astragaloside IV contents of 3 kinds of Shenqi Yangxue preparations were 0.193-1.976 mg/dose

with total solid weight of 31.297-103.077 g/dose and n-BuoH extract content of 6.11-14.55 g/dose. Conclusion: 3 preparation methods had significant difference in ratio of extraction

n-BuoH extract content and astragaloside IV content

so the preparation process had great effect on the evaluation indexes. The preparation method by vacuum concentrated machine had the best effect.