Objective: To investigate the effect of Shen'an granule on bone metabolism in 5/6 nephrectomy model rats. Method: Renal osteodystrophy (ROD) rat models were established using 5/6 nephrectomy. The rats were randomly divided into normal group

sham operation group

model group

positive drug calcitriol group (1.5 μg · kg-1)

Shen'an granules low dose group and high dose group (2.25

4.5 g · kg-1). Corresponding drugs were given by gavage for 8 weeks. Before and after treatment

blood urea nitrogen (BUN)

serum creatinine (SCr)

hemoglobin (HGB)

calcium (Ca)

phosphor (P)

and alkaline phosphatase (ALP) were detected;intact parathyroid hormone (iPTH) was detected with chemiluminescence method

and bone density was measured with dual energy X ray. Result: Compared with the normal group

BUN and SCr levels of ROD model rats were significantly increased (P<0.05)

HGB

serum Ca and bone density levels were significantly decreased (P<0.05)

serum P

ALP and whole iPTH levels were significantly increased (P<0.05). Compared with the model group

BUN and SCr levels in Shen'an granule 2.25

4.5 g · kg-1 dose groups were significantly decreased (P<0.05)

HGB

serum Ca and bone density levels were significantly increased(P<0.05)

serum P

ALP and whole iPTH levels were significantly decreased (P<0.05). Conclusion: Shen'an granule can significantly improve the renal function and bone metabolism indexes in 5/6 nephrectomy model rats

and delay progression of renal function and reduce the complications.