Objective: To investigate the clinical effect of Shengmai injection combined with glimepiride in the treatment of type 2 diabetes mellitus with Qi and Yin deficiency and its effect on inflammatory factors in serum. Method: Totally 152 patients with type 2 diabetes mellitus in our hospital during February 2013 to February 2015 were randomly divided into observation group (n=77) and control group (n=75). The patients in control group were treated with glimepiride therapy

while the patients in observation group were treated by Shengmai injection on the basis of glimepiride. The clinical efficiency

changes of fasting blood glucose (FBG)

postprandial 2 h blood glucose (2 h PBG)

and glycosylated hemoglobin (HbA1c)

changes in high-sensitivity c-reactive protein (hs-CRP)

tumor necrosis factor alpha (TNF-α)

and interleukin-1 beta (IL-1β)

as well as side effects between two groups were compared. Result: The total clinical effective rate was 92.21% in observation group

significantly higher than 78.67% in control group

with statistically significant difference between two groups (P<0.05). FBG

2 h PBG

and HbA1c were (5.87±0.32)

(6.52±1.22) mmol · L-1

and (4.42±0.37)% respectively in observation group

significantly lower than (10.63±0.53)

(11.24±2.72) mmol · L-1

and(6.21±0.52)% in control group

with statistical difference (P<0.05). After treatment

hs-CRP

TNF-α and IL-1β levels were significantly decreased in both groups (P<0.05)

and hs-CRP

TNF-α and IL-1β levels were (2.25±0.73) g · L-1

(1.56±0.47) ng · L-1

and (15.36±3.70) ng · L-1 in observation group

significantly lower than(3.37±1.01) g · L-1

(2.23±0.44) ng · L-1

and (22.94±3.81) ng · L-1 in control group

with statistical difference (P<0.05). The adverse reactions mainly included vomiting

diarrhea

and low blood sugar during treatment in two groups

and it was recovered after symptomatic treatment. There was no statistically significant difference in adverse reaction incidence between the two groups. Conclusion: Shengmai injection combined with glimepiride had an obvious effect in the treatment of type 2 diabetes mellitus with Qi and Yin deficiency

and can reduce the level of inflammatory factors

thus put off the incidence of complications of type 2 diabetes mellitus with Qi and Yin deficiency. It is worthy of clinical popularization.