Objective: To observe clinical efficacy of Wenxin decoction for unstable angina (UA). Method: A total of 228 patients with unstable angina and diagnosed as coronary heart disease via coronary angiography were enrolled in this study. Coronary artery stenosis occurred in 50%-70% of all the subjects

without any interventional therapy. In respect of traditional Chinese medicine syndrome

this disease was of phlegm and blood stasis stagnation with Yang Qi deficiency. The subjects were randomly divided into treatment group (n=118) and control group (n=110). Patients in treatment group were treated with Wenxin decoction+routine western medicine

while the patients in control group were treated with routine western medicine only. After 60 days of therapy

improvement of angina

consumption of nitroglycerin

changes of high sensitivity C reactive protein (hs-CRP) and low density lipoprotein cholesterol (LDL-C) before and after treatment were compared between two groups. The incidence of major adverse cardiovascular events (MACCE) within 60 days in two groups were compared. Result: There was no statistically significant difference in baseline clinical information between two groups. Total effective rate was 86.4% and 72.7% in treatment group and control group respectively after 60 days of treatment (P<0.01). After treatment

consumption of nitroglycerin was significantly reduced in treatment group

with significant difference as compared with control group (P<0.05). Levels of hs-CRP and LDL-C were also significantly reduced in treatment group

with significant difference as compared with control group (P<0.01). During the follow-up (54.5±8.5 days on average)

incidence of MACCE was 12.7% and 24.5% respectively in treatment group and control group (P<0.05)

and the non-lethal myocardial infarction rate was 1.7% and 10.0% respectively with statistically significant difference between two groups (P<0.01). There was no significant difference in incidence of revascularization

stroke and cardiac between two groups. Conclusion: Wenxin decoction has better effect in improving the angina symptoms and decreasing hs-CRP

LDL-C in the treatment of unstable angina. It could reduce the incidence of MACCE

especially the incidence of non-lethal myocardial infarction in patients with unstable angina.