Objective: To evaluate the efficacy of Xiyanping combined with Ribavirin in the treatment of children with Pediatric Herpangina. Method: Computer retrieval was conducted in Pubmed

Embase

Cochrane library

CNKI

CBM

Wanfang Data and VIP for randomized clinical trials on Xiyanping combined with Ribavirin in the treatment of children with Pediatric Herpangina. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies and made a Meta-analysis by using RevMan 5.3 software. Result: The 23 eventually included RCTs involved a total of 2 796 cases of children. Meta-analysis showed that Xiyanping combined with Ribavirin in the treatment of children with Pediatric Herpangina were statistically significant in total efficiency

temperature recovery time

herpes regression time compared with the control group (P<0.05). Subgroup analysis showeed Xiyanping combined with Ribavirin in the treatment of children with Pediatric Herpangina were superior to Xiyanping or Ribavirin alone. Conclusion: Xiyanping combined with Ribavirin in the treatment of children with Pediatric Herpangina have a certain efficacy and are superior to Xiyanping or Ribavirin alone. But due to the poor quality of the existing research

more restrictly-designed high-quality

multicenter

randomized

double-blind studies are required for further verification.