Objective: To screen optimal shaping and matching excipients of Tiaowei Chengqi granules for solving moldability

dissolvability

hygroscopicity and other issues. Method: With appearance

particle size

moisture content

dissolvability and hygroscopicity of granules as indexes

single factor tests were adopted to screen kinds

ratio and amounts of excipients

then quality verification

critical relative humidity and angle of repose were investigated. Result: Optimum molding materials was mixture of lactose and mannitol

ratio of extract-lactose-mannitol (1 : 3 : 1) for granulating

these prepared granules had uniform particle size

good properties and were not easy to moisture absorption.Critical relative humidity was 69% and angle of repose was less than 40°. Conclusion: These optimized excipients can significantly improve stability of Tiaowei Chengqi granules

and this molding process is scientific and rational.