Objective: To establish a quantitative analysis of multi-components with a single-marker (QAMS) method for the determination of eight components in Qianlielong Bitong tablets (polydatin

naringin

hesperidin

neohesperidin

epimedin A

epimedin B

epimedin C

icariin) and make more comprehensive assessment of the quality of the drug under 270

283 and 306 nm wavelengths of chromatogram using full-time multi-wavelength fusion technology. Method: With Qianlielong Bitong tablets as the research object and neohesperidin as the internal reference substances

the relative correlation factors (RCF) of polydatin

naringin

hesperidin

epimedin A

epimedin B

epimedin C

icariin to neohesperidin were calculated and established.The content of neohesperidin in the samples of Qianlielong Bitong tablets was determined by using the external standard method

and the contents of the other seven ingredients were calculated by their RCFs. The QAMS results were then compared with the external standard method results. Result: The values of 8 active constituents in four batches of Qianlielong Bitong tablets calculated by QAMS method were basically the same with the values calculated by external standard method

thus verify the feasibility and accuracy of QAMS method. Conclusion: The QAMS method is feasible and credible

and could be used to determine the multiple components in Qianlielong Bitong tablets.