Objective: To study the inhibition effect of compound Tufuling granules (CTG) on uric acid (UA)

activity of xanthine oxidase (XO)

and xanthine dehydrogenase(XDH) mRNA in hyperuricemic rats. Method: The 48 SD rats were randomly divided into normal group

model group

febuxostat group (4 mg · kg-1)

CTG low-dose group

CTG mid-dose group and CTG high-dose group (1

2

4 g · kg-1). Rats in all other groups except normal group were used to establish hyperuricemia (HUA) models and received corresponding drugs for intervention

once a day for 5 days. After experiment

UA of serum

activity of XO

and XDH mRNA in liver were detected. Result: In model group

levels of UA

activity of XO

and XDH mRNA expression levels in liver were significantly higher than normal group (P<0.05). After treatment

levels of UA

activity of XO

and XDH mRNA expression levels were significantly lower in various treatment groups than those in model group (P<0.05)

but there was no significant difference between CTG low dose group and model group. Conclusion: CTG may reduce the UA of serum

and inhibit the activity of XO and XDH mRNA expression level in hyperuricemic rats.