DAI Yong-na, WANG Zuo-shun. Comparison of Dispensing Granules and Traditional Decoction for Coronary Heart Disease Mixture[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(5): 182-187.
DAI Yong-na, WANG Zuo-shun. Comparison of Dispensing Granules and Traditional Decoction for Coronary Heart Disease Mixture[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(5): 182-187. DOI: 10.13422/j.cnki.syfjx.2016050182.
Objective: To compare and observe the clinical effect of dispensing granules and traditional decoction of coronary heart disease mixture on stable angina pectoris of coronary heart disease
Qi-stagnancy and blood stasis
and stagnation of Yang in chest. Method: The 252 patients were randomly divided into control group (n=126) and treatment group (n=126). Patients in treatment group were treated with dispensing granules of coronary heart disease mixture and routine west medicine; patients in control group were treated with traditional decoction of coronary heart disease mixture and routine west medicine. Before treatment
at week 2 of treatment
week 4 of treatment and after treatment (week 6)
traditional Chinese medicine(TCM) syndrome efficacy scores
Seattle angina scale scores
the changes of electrocardiogram(ECG)
blood lipid
blood rheology
left ventricular ejection fraction
nitroglycerin usage and other indexes were observed and compared. Symptoms of TCM syndrome
curative effect of Chinese and Western medicine
as well as quality of life were compared respectively. Result: Coronary heart disease mixture had good effect on patients with different degrees of angina pectoris. Total effective rate was 88.0% in treatment group (granule form) and 76% in the control group (traditional decoction form).Effect of different forms had no significant difference for mild and severe patients
but dispensing granules had more prominent effect for patients with moderate conditions. This may be related to its stability and content purity as well as the objective factors such as daily life of patients
requiring further deep research. Conclusion: Coronary heart disease mixture's dispensing granules have better efficacy than traditional decoction form
with certain clinical popularization value. It provides strong support for the improvement of Chinese medicine in the treatment of coronary heart disease and stable angina pectoris
not only adapts to the increasingly fast pace of work and life
but also provides overall solution for the application of TCM in modern society.