Objective: To introduce the research progress on toxicology of alkaloids in Sophorae Tonkinensis Radix et Rhizoma(STRR). Method: The studies on toxicity of STRR were summarized

analyzed and reviewed from clinical manifestations

laboratory studies and toxicity mechanism by accessing relevant information and references. Result: STRR has neurotoxicity

hepatotoxicity

cardiovascular toxicity

and can induce gastrointestinal side effects and allergic reaction. The toxicity was focused on gastrointestinal side effects and hepatotoxicity. However

neurotoxicity was most significant. Conclusion: Alkaloids of STRR are the material basis for toxic reaction. Both matrine and oxymatrine are the major toxic components of STRR. Overdose is a major cause of poisoning and the mechanism of toxicity is primarily related to the inhibition of acetylcholinesterase activity and oxidative stress as well as inflammatory injury.