不同促渗剂对三威跌打风湿贴中柚皮苷体外透皮吸收的影响

银杉杉; 汪艳秋; 周国良; 张军

doi:10.13422/j.cnki.syfjx.2016070015

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不同促渗剂对三威跌打风湿贴中柚皮苷体外透皮吸收的影响

药剂与炮制 | 更新时间：2024-01-04

- 不同促渗剂对三威跌打风湿贴中柚皮苷体外透皮吸收的影响
- Effects of Different Permeation Enhancer on Percutaneous Absorption of Naringin in Sanwei Dieda Rheumatism Gel Paste
- 中国实验方剂学杂志 2016年22卷第7期页码：15-18
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- DOI：10.13422/j.cnki.syfjx.2016070015
  中图分类号： R283.6
- 纸质出版日期：2016
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银杉杉, 汪艳秋, 周国良, 等. 不同促渗剂对三威跌打风湿贴中柚皮苷体外透皮吸收的影响[J]. 中国实验方剂学杂志, 2016,22(7):15-18.

YIN Shan-shan, WANG Yan-qiu, ZHOU Guo-liang, et al. Effects of Different Permeation Enhancer on Percutaneous Absorption of Naringin in Sanwei Dieda Rheumatism Gel Paste[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(7): 15-18.
银杉杉, 汪艳秋, 周国良, 等. 不同促渗剂对三威跌打风湿贴中柚皮苷体外透皮吸收的影响[J]. 中国实验方剂学杂志, 2016,22(7):15-18. DOI： 10.13422/j.cnki.syfjx.2016070015.

YIN Shan-shan, WANG Yan-qiu, ZHOU Guo-liang, et al. Effects of Different Permeation Enhancer on Percutaneous Absorption of Naringin in Sanwei Dieda Rheumatism Gel Paste[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(7): 15-18. DOI： 10.13422/j.cnki.syfjx.2016070015.

摘要

目的: 研究三威跌打风湿贴中柚皮苷体外透皮吸收行为

比较不同透皮吸收促进剂对其透皮吸收性能的影响。方法: 采用Franz扩散池装置

以HPLC测定接收液中柚皮苷含量

流动相0.1%磷酸-乙腈(81:19)

检测波长283 nm

考察制剂中柚皮苷体外透皮吸收行为及各促透剂的促渗效果。结果: 不含促渗剂的凝胶膏剂中柚皮苷体外透皮吸收符合零级释放模型

24 h体外累积渗透方程Q=1.126t+2.795

透皮速率1.126 μg ·cm-2 ·h-1;加入促透剂丙二醇、氮酮、薄荷脑后柚皮苷体外透皮吸收速率明显提高

且薄荷脑 >丙二醇 >氮酮。结论: 凝胶膏剂中柚皮苷可透皮吸收;促透剂丙二醇、氮酮、薄荷脑均能促进柚皮苷透皮吸收

且以薄荷脑作用最明显。

Abstract

Objective: To investigate effects of different permeation enhancer on in vitro percutaneous absorption of naringin in Sanwei Dieda rheumatism gel paste. Method: Taking Franz diffusion cell to perform test

HPLC was adopted to determine the content of naringin in receiving liquid

effects of different permeation enhancer on in vitro percutaneous absorption of naringin in Sanwei Dieda rheumatism gel paste were investigated. Result: In vitro percutaneous absorption of naringin in this gel paste accorded with zero order release model

cumulative permeation equation was Q=1.126t+2.795 with transdermal rate of 1.126 μg · cm-2 · h-1.Either propylene glycol

azone or menthol was added

transdermal rates of naringin were improved

and effect was in order of menthol > propylene glycol > azone. Conclusion: Naringin in gel preparation can be percutaneous absorded.Propylene glycol

azone and menthol all can obviously promote transdermal absorption of naringin

especially for menthol

which plays the highest effect.

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