Objective: To optimize extraction technology of Shuanghuang Erxian granules. Method: HPLC was employed to determine contents of astragaloside Ⅳ and complanatuside in Shuanghuang Erxian granules with mobile phases of acetonitrile-water (35 : 65) and acetonitrile-0.2% phosphoric acid solution (21 : 79)

respectively.Taking contents of astragaloside Ⅳ and complanatuside

yield of dry extract as comprehensive evaluation index

orthogonal test was used to investigate effects of water amount

extracting time and times on extraction process of Shuanghuang Erxian granules. Result: Optimum extraction condition was as follows:extracted twice with 8 times the amount of water

1 hour for per time.Extracting amounts of astragaloside Ⅳ and complanatuside were 1.084

1.343 mg · g-1

yield of dry extract was 28.48%

extraction time had a significant effect on extraction technology of Shuanghuang Erxian granules. Conclusion: This optimized extraction condition is stable and feasible

it can provide guidance for industrial production of Shuanghuang Erxian granules.