Objective: To explore the effect of Lespedeza Bicoloris Radix extracts (LBE) on animal models of uterine fibroid and blood stasis rats. Method: KM mice of the same birth date and SD rats of the same birth date were divided into normal groups and model groups. Estradiol benzoate was used in modeling animals to induce uterine fibroid rat models and uterine fibroid mice models. The modeling rat groups were randomly divided into model group

Tamoxifen citrate tablets positive group (0.18 g · kg-1) and LBE high dose

middle dose and low dose groups (1.0

0.5

0.25 g · kg-1). The modeling mice were randomly divided into model group

Tamoxifen citrate tablets positive group (0.23 g · kg-1) and LBE high dose

middle dose and low dose groups (1.4

0.7

0.35 g · kg-1). The rats were randomly divided into normal group

model group

Compound Danshen tablets positive group (0.34 g · kg-1) and LBE high dose

middle dose and low dose groups (1.0

0.5

0.25 g · kg-1). All the other rats except normal group received subcutaneous injection of adrenaline hydrochloride in back. 2 h later

rats received dipping bath in ice water to induce acute blood stasis mice models. After continuous drug administration for two weeks

uterus coefficient

uterine dry weight

serum estrogen level

and pathological changes of uterus in uterine fibroid animal models and blood rheology in blood stasis rats were observed. Result: After continuous administration for two weeks

uterus coefficient

uterine dry weight

and serum estrogen levels were decreased in uterine fibroid rats and mice LBE groups

and the pathological changes were alleviated in uterine fibroid mice;whole blood viscosity

plasma viscosity

whole blood high shear relative index

whole blood low shear relative index

and erythrocyte aggregation index were decreased in blood stasis rats (P<0.01

P<0.05). Conclusion: LBE has a certain therapeutic effect on animal models of uterine fibroid.