Objective: To investigate the clinical efficacy of Duhuo Jisheng Tang combined with meloxicam in the treatment of rheumatoid arthritis (RA)

and observe its effect on serum interleukin-1 (IL-1)

tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule (ICMAM-1) levels. Method: The 92 cases of rheumatoid arthritis in our hospital from April 2012 to December 2014 were selected as the research objects

and were divided into two groups according to the random number table method. Patients in control group (45 cases) were treated with meloxicam (15 mg · time-1

1 time · d-1) by orally taking

and also with symptomatic and supportive treatment. Patients in test group (47 cases) were also given with Duhuo Jisheng Tang based on treatment in control group. Treatment course was 12 weeks for both groups. Clinical symptoms in both groups were observed and recorded before and after treatment

such as morning stiffness time

swelling index

tenderness index

20 m walking time

two-hand grip and activities of daily living score in Health Assessment Questionnaire (HAQ). In addition

C-reactive protein (CRP) treatment

erythrocyte sedimentation rate (ESR)

rheumatoid factor (RF)

IL-1

TNF-α and ICMAM-1 levels were detected before and after treatment. Result: According to standards on RA conditions recommended by American College of Rheumatology

total effective rate was 97.9% in test group

significantly higher than 82.2% in control group (P<0.05). After treatment for 12 weeks

duration of morning stiffness

swelling index

tenderness index

20 m walking time

hand grip and HAQ indexes were significantly improved in both groups

with significant difference when compared with conditions before treatment (P<0.01). Improvement degree in above indexes in test group was more significant than that in control group

with significant difference (P<0.01). Levels of CRP

ESR

RF

IL-1

TNF-α

and ICMAM-1 were significantly decreased in both groups

with significant difference when compared with the conditions before treatment (P<0.01). Decrease degree in above indexes in test group was more significant than that in control group

with significant difference(P<0.01). Conclusion: Duhuo Jisheng Tang combined with meloxicam in the treatment of RA has good clinical effect

significantly improves the clinical symptoms of patients

and has certain inhibitory effect on the body's inflammatory response

worthy of clinical use.