Objective: To investigate the clinical efficacy of Jiangzhi Hugan Tang in treatment of non-alcoholic steatohepatitis (NASH) in different physiques and observe its effect on anti-oxidative stress of liver. Method: One hundred NASH patients were randomly divided into control group (50 cases) and treatment group (50 cases) according to random number table. Patients in two groups were given with non-drug basic treatment referring to Consensus on the diagnosis and management of non-alcoholic fatty liver disease by Integrated Chinese and western medicine. Patients of control group were also treated with diammonium glycyrrhizinate tablets

150 mg/time

tid. Patients of treatment group were also treated with Jiangzhi Hugan Tang (1 dose/d and bid). The treatment course was 3 months for both groups. Changes in blood lipid level and liver function were compared between the two groups before and after treatment. Changes of clinical symptoms and signs were observed in both groups and the clinical efficacy was retrospectively analyzed as well. Levels of total superoxide dismutase (SOD)

glutathione peroxidase(GSH-Px)

reduced glutathione (GSH) and malondialdehyde (MDA) in serum were measured in two groups. Result: Levels of triglycerides (TG)

total cholesterol (TC) and low density lipoprotein (LDL) were in treatment group were significantly lower than those in control group

while the level of high density lipoprotein (HDL) was significantly higher in treatment group(P<0.01). Levels of alanine aminotransferase (ALT)

aspartate transaminase (AST)

total bilirubin (TBIL)

γ-Glutamine transpeptidase (γ-GT) and scores of Chinese medicine physiques in treatment group were significantly lower than those in control group after treatment (P<0.01). The total efficacy of treatment group was 94%

higher than 76% in control group (P<0.05). Levels of SOD

GSH-Px and GSH in serum of treatment group were significantly higher than those in control group

however MDA level was significantly lower than that of control group

with statistical difference (P<0.01). Conclusion: Jiangzhi Hugan Tang in treatment of NASH by different physiques could protect hepatic function

ameliorate the lipid disturbance and scores of Chinese medicine physiques

and improve clinical efficacy. It is suggested that one of the mechanisms above might be associated with strengthening hepatic capacities of anti-oxidation stress.