Objective: To observe the effect of Zhongfeng Fangzhiling capsule on preventing and treating restenosis after stent implantation for carotid artery stenosis. Method: The 60 postoperative patients with stent implantation for carotid artery stenosis were randomly divided into 2 groups

with 30 cases in each group. Patients in control group were treated with aspirin and clopidogrel. Patients in treatment group were also treated with Zhongfeng Fangzhiling capsule by orally taking based on the treatment in control group. Patients in both groups were treated for 180 days. Patients in both groups were observed for restenosis rate

carotid color Doppler ultrasound

transcranial doppler (TCD) detection

thromboxane A2(TXA2)

prostaglandin I2 (PGI2)

and blood rheology changes. Result: Total effective rate was 90.0% by combined Chinese and western medicine in treatment group

higher than 73.3% in control group(P<0.05). The stenosis rate in lesion of control group higher than in treatment group(P<0.05). The clinical efficacy

TCM symptom scores

and scores of wind-phlegm stasis syndrome in Zhongfeng Fangzhiling capsule combined with western medicine group were significantly superior to those in western medicine alone group. In addition

Zhongfeng Fangzhiling capsule combined with western medicine could significantly reduce the unstable plaque of internal carotid

plaque length

plaque thickness

improve blood rheology

lower the TXA2 level

increase the level of PGI2

and can reduce the incidence of recent bleeding (complication)

with better effect than western medicine alone. One year after the implantation

no transient ischemic attack (TIA) or cerebral infarction was found in patients in the clinical follow-up. Conclusion: Zhongfeng Fangzhiling capsule combined with western medicine has better efficacy in preventing and treating restenosis after stent implantation for carotid artery stenosis

and can reduce the incidence of recent bleeding (complication).