Triptergium wilfordii (TW) is a characteristic traditional Chinese medicine (TCM) in China

with certain effect for autoimmune hyperthyroidism diseases like rheumatoid arthritis (RA). In recent years

it has been one of the hot natural medicines both at home and abroad for functions of anti-inflammatory

anti-tumor

immunomodulatory

anti-fertility

anti-HIV virus and treatment of Alzheimer's disease. However

multiple-organ injury is common in the clinical application of TW

especially the frequent renal toxicity and serious consequences of poisoning. Therefore

application and promotion of TW are restricted. In this paper

we would explore the prescription rules of TW based on the previous researchers' text mining experience

explore and summarize the rules of TCM prescriptions through in-depth analysis and classification. Meanwhile

we would put forward the combination principles of detoxicity prescriptions on renal toxicity of TW compatibility based on "toxicity restriction by strengthening the body resistance" methods under the guidance of the theory of "diversity restriction". For the clinical toxicity and adverse effect of TW

right medicines were selected for compatibility with TW for detoxicity

in order to make them play a comprehensive role in the complementary and opposite phase system with TW

and provide references for improving the security of the clinical application of TW.