Objective: To observe the short-term effect amd safety of Yangzheng Xiaoji capsule in the treatment of cancer cachexia

and provide theory basis for its clinical treatment. Method: Totally 70 patients with cancer cachexia were randomly divided into observation group and control group

35 cases in each group. Patients of both groups received diet guidance and general nutrition support. Patients in observation group also orally took Yangzheng Xiaoji capsules

4 tablets/time

3 times/d;while the patients in control group orally took megestrol acetate tablets

160 mg/time

1 time/d. Observation period lasted for 1 month. Traditional Chinese medicine (TCM) symptom scores

food-intake and middle upper arm circumference of both groups were observed before and after treatment. Quality of life (QOL) was graded

and the level of serum albumin

hemoglobin

T lymphocyte subsets and adverse reactions were also detected. Result: After treatment

the TCM symptom efficacy and food-intake in the observation group were superior to those in the control group (P<0.05). After treatment

middle upper arm circumference of patients in the observation group and control group were (24.58±2.21) score and (24.01±2.29) score respectively

with an increase as compared with those before treatment

but there was no statistically significant difference between two groups. The QOL score was (36.52±3.39)score and (34.80±3.46)score for observation group and control group respectively

with an increase as compared with those before treatment

but the improvement of QOL score in observation group was more significant than that of control group (P<0.05). The levels of serum albumin

hemoglobin and CD3+

CD4+

CD8+

CD4+/CD8+ cells were significantly improved after treatment in both groups (P<0.01

P<0.05). However

the improvement in the observation group was more significant than that in control group after treatment (P<0.05).There was no adverse reaction in the observation group. Conclusion: Yangzheng Xiaoji capsule could effectively improve TCM symptoms for patients with cancer cachexia

increase food-intake

improve quality of life and significantly improve serum albumin

hemoglobin and T lymphocyte subsets level. It is much more better than megestrol acetate in clinical efficacy and safety. Yangzheng Xiaoji capsule deserves much more clinical research and application.