Objective: To systematically review the effectiveness of Yiqi Fumai injection combined with western medicine for heart failure. Method: Databases such as PubMed

CENTRAL

EMbase

VIP

CNKI

CBM and Wanfang were electronically searched to collect the randomized controlled trials (RCTs). After document screening and quality evaluation

Meta-analysis was conducted for valid data. Result: Thirteen RCTs involving 1001 patients were included. The results of meta-analysis showed that the combination of Yiqi Fumai injection and western medicine was superior to the western medicine alone in improving clinical comprehensive efficacy[OR=3.09

95%CI (2.05

4.67)

P<0.00001]

left ventricular ejection fraction[MD=4.84

95%CI (3.56

6.13)

P<0.00001]

cardiac output[MD=0.30

95%CI (0.19

0.42)

P<0.00001]

6 minutes walking distance[MD=39.03

95%CI (25.06

53.00)

P<0.00001]

reducing NT-proBNP[MD=-67.72

95%CI (-110.30

-25.13)

P=0.002]

and shortening left ventricular end systolic dimension (LVESD)[MD=-2.94

95%CI (-4.86

-1.02)

P=0.0003]

with statistically significant differences between two groups. But there was no significant difference between two groups in shortening left ventricular end diastolic dimension (LVEDD)[MD=-2.06

95%CI (-4.70

0.58)

P=0.13]and improving E/A[MD=0.06

95%CI (-0.03

0.15)

P=0.21]. Conclusion: Combination of Yiqi Fumai injection and western medicine has higher clinical efficacy than western medicine alone for the treatment of heart failure.