Objective: To assess the clinical effects and safety of Chinese medicine injection combined with transcatheter arterial chemoembolization (TACE) for liver cancer by using network Meta-analysis. Method: The randomized controlled trials (RCTs) of Chinese medicine injections (CMIs) combined with TACE VS TACE alone for liver cancer were searched from PubMed

The Cochrane Library

EMBASE

CBM

Chinese Knowledge Infrastructure (CNKI)

Wanfang

and Chinese Scientific Journals Fulltext Database (VIP-CSJFD)

up to March 2015 since database establishment. The RCTs were screened and selected according to the predefined inclusion and exclusion criteria Data extraction and quality evaluation were done for the included RCTs by 2 independent researchers

and Bayesian network meta-analysis was done by using WinBugs 1.4 software. Result: The 91 RCTs including 6 493 patients were finally included. The results of network Meta-analysis showed that 7 kinds of CMIs combined with TACE were superior to TACE alone in the treatment of liver cancer in increasing effective rate and life quality

reducing nausea and vomiting

abnormal liver function and leukopenia incidence. In terms of efficacy for liver cancer

Kang'ai injection+TACE

Fufang Kushen injection+TACE

Aidi injection+TACE

Kanglaite injection+TACE

cinobufagin injection+TACE

and bruceolic oil emulsion injection+TACE were superior to astragalus polysaccharide injection+TACE

whereas there was no statistically significant difference with other injections+TACE. In terms of improving life quality

Fufang Kushen injection+TACE was prior to Aidi injection+TACE. There was no statistically significant difference among the 7 CHIs in reducing the incidence of nausea

vomiting and leukopenia. Conclusion: Based on the results of network Meta-analysis

7 CHIs combined with TACE have better efficacy and safety than TACE alone for liver cancer. Based on the probability ranking results

Kang'ai injection+TACE is more effective as compared with other 6 CHIs+TACE for increasing effective rate

and cinobufagin injection+TACE is more effective as compared with other 6 CHIs+TACE for improving the quality of life.