Objective: To study on pharmacokinetic characteristics of ellagic acid microspheres in rabbits by oral administration. Method: Orifice method was used to prepare ellagic acid microspheres

HPLC was employed to determine the concentration of ellagic acid with acetonitrile-0.1% phosphoric acid solution (23:77) at a flow rate of 0.8 mL·min-1

detection wavelength was set at 254 nm

column temperature was controlled at 30℃.Pharmacokinetic parameters differences of ellagic acid microspheres and ellagic acid tablets were analyzed by DAS 2.0. Result: The linear range of ellagic acid was within 0.01-1.50 mg·L-1 with r of 0.999 4

quantitation limit was 0.01 mg·L-1.Plasma concentration-time curve of ellagic acid showed double peak

there may be enterohepatic circulation in rabbits.Pharmacokinetic of ellagic acid microspheres could be evaluated by two-compartment model.Main pharmacokinetic parameters were shown as t1/2β of (7.683±2.762) h

t1/2α of (7.161±1.275) h

tmax of (3.00±0) h and Cmax of (1.121±0.259) mg·L-1. Conclusion: By comparing with ellagic acid tablets

ellagic acid microspheres exhibits higher bioavailability and longer action duration in rabbits.