Objective: To investigate efficacy of Erxian Bushen decoction combined with warm acupuncture in treating post-menopause osteoporosis(PMOP) with syndrome of kidney-Yang deficiency and its influences on levels of serum peroxidase body growth activated receptor γ synergy stimulating factor 1-α (PGC-1α)

steroid receptor auxiliary activation factor 3 (SRC-3)

estrogen-related receptor α(ERRα)

and osteopontin (OPN) levels. Method: One hundred and twenty-four eligible cases were randomly divided into control group and treatment group (62 cases of each group) by random number table. Patients of control group were treated with alendronate sodium tablets (70 mg/time and 1 time/week) and calcium carbonate D3 tablets (qd). Based on the treatment of control group

patients in treatment group were also treated with Erxian Bushen decoction (1 dose/d and bid) combined with warm acupuncture (1 time/3 d). The treatment course was 6 months for both groups. Traditional Chinese medicine (TCM) symptom scores

bone mineral density (BMD) of right femoral neck and anteroposterior position of lumbar spine (L2-4) were compared between two groups. Levels of PGC-1α

SRC-3

ERRα

and OPN in serum were detected in two groups. Result: The TCM symptom scores in treatment group were lower than those of control group after treatment (P<0.01). Clinical total effective rate was 91.94% in treatment group

significantly higher than 77.42% in control group (P<0.05). BMD levels of right femoral neck and L2-4 in treatment group were significantly higher than those of control group after treatment (P<0.01). Levels of PGC-1α and SRC-3 in serum of treatment group were significantly higher than those of control group after treatment

while ERRα and OPN levels were significantly lower

with statistical differences (P<0.01). Conclusion: On the basis of western medicine routine treatment

Erxian Bushen decoction combined with warm acupuncture in treating PMOP with syndrome of kidney-Yang deficiency could obviously improve clinical symptoms

increase BMD levels of right femoral neck and L2-4

and improve clinical efficacy

which may be related with increasing the levels of PGC-1α and SRC-3 in serum and inhibiting levels of ERRα and OPN.