Objective: To investigate the clinical efficacy of modified Buyang Huanwu detection in treating traumatic peripheral nerve injury with arteries and veins stasis and its influence on levels of nuclear factor-κB (NF-κB) and tumor necrosis factor-α(TNF-α) in serum. Method: Ninety-two cases with traumatic peripheral nerve injury were randomly divided into control group (46 cases) and treatment group (46 cases) by random number table. Patients in control group were treated with mecobalamin tablets by orally taking (1 tablet/time

tid) and electrical stimulation therapy (25 min/time

qd

and 6 times/week). Based on treatment in control group

patients of treatment group were also treated with modified Buyang Huanwu detection

1dose/d and bid. Treatment course was 3 months for both groups. Traditional Chinese medicine(TCM) symptom scores were compared between two groups pre-post treatment. Motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) were detected. Levels of NF-κB and TNF-α in serum were detected in two groups pre-post treatment. Result: TCM symptom scores in treatment group were significantly lower than those of control group after treatment (P<0.01). Cure-remarkable-effectiveness rate was 80.43% in treatment group

significantly higher than 56.52% in control group

with statistical differences (P<0.05). MNCV and SNCV levels of median nerve

ulnar nerve

radial nerve

nervus tibialis

and nervus peroneus communis in treatment group were higher than those of control group (P<0.01). After treatment

the levels of NF-κB and TNF-α in serum of treatment group were significantly lower than those of control group

with statistical differences (P<0.01). Conclusion: On the basis of western medicine treatment

modified Buyang Huanwu detection in treating traumatic peripheral nerve injury with arteries and veins stasis could obviously improve clinical symptoms and increase the conduction velocity of motor nerve and sensory nerve

with better clinical efficacy than western medicine alone. Inhibiting the levels of NF-κB and TNF-α in serum may be one of its mechanisms.