Objective: Obesity has become one of the crucial social health problems.Yet there are many controversies

it is extensively accepted that simple obesity is based on energy absorption greater than consumption

leading to a lot of fat accumulation.Reasons for obesity formation are quite complex

intestinal flora imbalance

energy metabolic disorders

low level of inflammatory and immune dysfunction are the main causes.The present work reviews current advances on exploration of relationships of immune dysfunction with nutritional obesity

and cross interaction among immune

endocrine and metabolism.We conclude that obesity is closely related to body's immune status.Our group will continue to verify feasibility of this theory in the next experiment

in order to find new targets and methods for obesity treatment based on intestinal mucosal immune

it can provide novel thought for treatment of obesity and related metabolic diseases.