Objective: To observe the clinical efficacy of Ansheng Dingzhiling recipes in children with Tourette syndrome (TS). Method: The 120 cases of children with TS were randomly divided into experimental group and control group

with 60 cases in each group. Patients in experimental group took Ansheng Dingzhiling recipes according to the clinical syndrome

while patients in control group orally took haloperidol tablets

from the beginning of 0.05 mg·kg-1·d-1

2 times a day. The treatment course was 2 months for both groups

and patients were observed once every two weeks for a total of 2 months. Yale Global Tic Severity Scale (YGTSS) and traditional Chinese medicine (TCM) syndrome grading and classification scale were used to record the changes of TS symptom scores before and after treatment

compare the efficacy and adverse reactions between two groups

and find the rules of TCM syndrome changes in experimental group by statistical method. Result: YGTSS results were as follows

the experimental group:clinical control in 5 cases (8.3%)

marked effect in 45 cases (75%)

progress in 10 cases (16.7%)

and ineffective in 0 case (0%)

with a controlled and effective rate of 83.3%

control group:clinical control in 7 cases (11.7%)

marked effect in 41 cases (68.3%)

progress in 12 cases (20%)

and ineffective in 0 case (0%)

with a controlled and effective rate of 80%. TCM syndrome grading and classification scale results were as follows

experimental group:clinical control in 4 cases (6.7%)

marked effect in 47 cases (78.3%)

progress in 9 cases (15%)

and ineffective in 0 case (0%)

with a controlled and effective rate of 85.0%

control group:clinical control in 6 cases (10%)

marked effect in 46 cases (76.7%)

progress in 8 cases (13.3%)

and ineffective in 0 case (0%)

with a controlled and effective rate of 86.7%. Statistically

there was significant difference before and after treatment in both groups (P < 0.01)

but the difference was not statistically significant between two groups. The incidence of adverse reactions in the experimental group was superior to that of control group. Conclusion: Staged treatment with Anshen Dingzhiling recipes had equivalent effect for Tourette syndrome as compared with western medicine

haloperidol

but the adverse reactions of Anshen Dingzhiling recipes were less than lower than

haloperidol

worthy of further in-depth research.