To explore the characteristics of Glycyrrhizma Radix et Rhizoma in treatment of the depression. Related literature about Chinese medicine Glycyrrhizma Radix et Rhizoma for treatment of the depression in recent years was looked up to analyze the characteristics of Glycyrrhizma Radix et Rhizoma for the treatment of depression from the perspectives of antidepressant active ingredients and its application in Chinese medicine compounds. Glycyrrhizma Radix et Rhizoma has been widely used in the treatment of depression

with good curative effect in improving animal behavior and biochemical indicators

and the mechanism is mainly associated with regulating monoamine neurotransmitter and receptors in the brain

improving the hypothalamus-pituitary-adrenal (HPA) axis function

anti-free radicals

and anti-inflammatory effects. Glycyrrhizma Radix et Rhizoma treatment for depression has stable efficacy

long-lasting effect and less adverse reactions

providing for ideas and references for clinical screening of the antidepressant Chinese medicine active ingredients and prescription compatibility.