星点设计-响应面法优化石菖蒲挥发油羟丙基--环糊精的包合工艺

王月亮; 陈凯; 李慧; 张晓莉; 刘宇灵; 王佳奇; 刘文丛

doi:10.13422/j.cnki.syfjx.2016110020

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星点设计-响应面法优化石菖蒲挥发油羟丙基--环糊精的包合工艺

药剂与炮制 | 更新时间：2024-01-04

- 星点设计-响应面法优化石菖蒲挥发油羟丙基--环糊精的包合工艺
- Optimization of Inclusion Process of Volatile Oil from Acori Tatarinowii Rhizoma and Hydroxypropyl--cyclodextrin by Central Composite Design-response Surface Methodology
- 中国实验方剂学杂志 2016年22卷第11期页码：20-24
- 作者机构：
- 作者简介：
- 基金信息：
  
  中国中医科学院自主选题(Z02063);北京市共建项目专项
- DOI：10.13422/j.cnki.syfjx.2016110020
  中图分类号： R283.6
- 纸质出版日期：2016
- 稿件说明：
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王月亮, 陈凯, 李慧, 等. 星点设计-响应面法优化石菖蒲挥发油羟丙基--环糊精的包合工艺[J]. 中国实验方剂学杂志, 2016,22(11):20-24.

WANG Yue-liang, CHEN Kai, LI Hui, et al. Optimization of Inclusion Process of Volatile Oil from Acori Tatarinowii Rhizoma and Hydroxypropyl--cyclodextrin by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 20-24.
王月亮, 陈凯, 李慧, 等. 星点设计-响应面法优化石菖蒲挥发油羟丙基--环糊精的包合工艺[J]. 中国实验方剂学杂志, 2016,22(11):20-24. DOI： 10.13422/j.cnki.syfjx.2016110020.

WANG Yue-liang, CHEN Kai, LI Hui, et al. Optimization of Inclusion Process of Volatile Oil from Acori Tatarinowii Rhizoma and Hydroxypropyl--cyclodextrin by Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 20-24. DOI： 10.13422/j.cnki.syfjx.2016110020.

摘要

目的: 优选石菖蒲挥发油羟丙基-β-环糊精(HP-β-CD)包合物的制备工艺

为该部位的有效利用提供参考。方法: 以挥发油包合率、包合物得率和包合物中α-细辛醚质量分数的综合评分为评价指标

采用星点设计-效应面法考察包合时间、包合温度、主客体配比对石菖蒲挥发油HP-β-CD包合工艺的影响

以红外光谱法(IR)和气相色谱-质谱法(GC-MS)对该包合物进行质量评价。结果: 石菖蒲挥发油HP-β-CD包合物的最佳包合工艺为包合时间3.85 h

包合温度30.06℃

HP-β-CD与石菖蒲挥发油投料比8.69:1。挥发油包合率79.74%

包合物得率87.47%

包合物中α-细辛醚质量分数2.266 mg·g-1。石菖蒲挥发油包合前后GC-MS图谱的整体相似度高。结论: IR和GC-MS分析包合物结果证明包合物制备成功

石菖蒲挥发油在包合前后成分变化不大。星点设计-效应面法适用于石菖蒲挥发油HP-β-CD包合物的工艺优化。

Abstract

Objective: To optimize the preparation process of inclusion complex of volatile oil from Acori Tatarinowii Rhizoma and hydroxypropyl-β-cyclodextrin (HP-β-CD). Method: Taking composite score of inclusion rate of volatile oil

yield of inclusion complex and the content of α-asarone as index

central composite design-response surface methodology was adopted to optimize inclusion process with inclusion temperature

reaction time

ratio of HP-β-CD and volatile-oil as factors. The quality of inclusion complex was evaluated by infrared spectroscopy (IR) and GC-MS. Result: The best process was as follows

inclusion time was 3.85 h

inclusion temperature was 30.06℃

ratio of HP-β-CD and volatile-oil was 8.69: 1. Under these conditions

inclusion rate of volatile oil was 79.74%

yield of inclusion complex was 87.47%

the content of α-asarone in inclusion complex was 2.266 mg·g-1. After inclusion

similarities of GC-MS spectra of volatile oil was high. Conclusion: The characterization results of IR and GC-MS proved the generation of inclusion complex. Central composite design-response surface methodology is suitable for optimizing inclusion process of inclusion complex of volatile oil from Acori Tatarinowii Rhizoma and HP-β-CD.

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