Objective: To provide foundation for further exploring the differences in hypevplasiasuppressorgene(HSG) expressions before and after Chinese medicine prescription treatment for different traditional Chinese medicine (TCM) syndromes of chronic obstructive pulmonary disease (COPD)

and provide objective standards for diagnosis of COPD TCM syndromes by detecting the expression of HSG in different TCM syndromes of COPD. Method: The 110 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and 30 normal people were randomly selected as the study subjects. They were divided into normal group

Qi deficiency group

phlegm heat group

and phlegm turbidity group. Blood was taken in fasting state in all inductees. The kit method was used to extract total RNA from the blood

mRNA expressions of HSG under different groups of AECOPD patients was detected by Real-time PCR

the protein expression of HSG under different groups of AECOPD patients was detected by Western bolt. Result: There was significant difference between normal group and phlegm turbidity group

phlegm heat group

Qi deficiency group. Conclusion: The expression levels of HSG were low in AECOPD patients and high in normal group. Expression levels of HSG in blood of Qi deficiency group were lower than those in phlegm turbidity group and phlegm heat group. HSG and COPD development may have an inherent correlation and HSG expression levels may affect airway reconstruction. It may be involved in the formation of different TCM syndromes in COPD.